meta-analysis of randomized trials (incompatible protocols & patient populations)
after all, the only thing that matters is the truth
but what is the truth, asked pilate?
randomized trials
highly selected patients
platonic ideal of clinical trial setting to prove efficacy
yet what really matters is effectiveness in the real world
observational studies
constrained by budgets and ethics
heraclitean agile approach to real patients
propensity score matching, instrumental variables, etc.
big data
electronic health records, insurance claims, registries, web-based surveys, wearable devices, social media, etc.
epicurean pragmatic approach to real patients
machine learning, natural language processing, etc.
case series, reports and anecdotes (historical medical literature and classical medical education)
expert opinion (clinical experience and intuition especially in the absence of evidence, say, in the case of a novel disease)
references: bible, talmud, koran, bhagavad gita, etc.
hey co-pilot how to i use references.bib in jupyter notebooks?
step 1: install jupyterlab-bib extension
step 2: install jupyterlab-latex
step 3: install jupyterlab-katex
step 4: install jupyterlab-citation-manager